中国·太阳成-www.tyc7111cc-集团官网

天然产物的结构修饰及靶向小分子药物的设计、合成等研究。

1.Lijiao Wang, Lei Hu, Jianlin Deng, Suyan Hou, Luohe Mou, Pengcheng Lei, Xi Chen, Jiayu Liu, Yingying Jiang, Rui Xiong, Xiangqin Tian, Weifeng Zhan, Rong Li, Wenyu Yang, Lingling Yanga. Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors. Bioorganic & Medicinal Chemistry, 2023, 93, 117455. 

2.Dongmei Fan, Pingxian Liu, Yunhan Jiang, Xinlian He, Lidan Zhang, Lijiao Wang, and Tao Yang. Discovery and SAR Study of Quinoxaline–Arylfuran Derivatives as a New Class of Antitumor Agent. Pharmaceutics, 2022, 14, 2420. 

3.LiJiao Wang, Rong Li, Chen Song, Yanli Chen, Haiyue Long, Lingling Yang. Small Molecules Anti-Cancer Drugs from the Year 2016 to 2020: Synthesis and Clinical Application. Natural product communications, 2021, 16(9): 1-42.

4.LiJiao Wang, Zhi-Xing Cao, and Li Guo. Design, Synthesis, and Preliminary Antitumor Activity Evaluation of Novel Alkaloid Derivatives. Natural product communications, 2020, 15(2): 1-7. 

5.Lijiao Wang, Chao Li, Wei Chen, Chen Song, Xing Zhang, Fan Yang, Chen Wang, Yuanyuan Zhang, Shan Qian, Zhouyu Wang, and Lingling Yang. Discovery of (5-Phenylfuran-2- yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors. Molecules, 2019, 24(15), 2724. 

6.Jiao Yang, Li-Jiao Wang, Jing-Jing Liu, Lei Zhong, Ren-Lin Zheng, Yong Xu, Pan Ji, Chun-Hui Zhang, Wen-Jing Wang, Xing-Dong Lin, Lin-Li Li, Yu-Quan Wei, and Sheng-Yong Yang. Structural Optimization and Structure–Activity Relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations , Journal of Medicinal Chemistry, 2012, 55, 23, 10685-10699.

主讲《中药化学》《药物合成》《制药过程设计及模拟训练》等课程。